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TeachMeFinance.com - explain Synergistic effect Synergistic effect The term 'Synergistic effect' as it applies to the area of hazardous materials can be defined as 'A biologic response to multiple substances where one substance worsens the effect of another substance. The combined effect of the substances acting together is greater than the sum of the effects of the substances acting by themselves [see additive effect and antagonistic effect]'.
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